Valproic Acid

Valproic Acid 

Valproic Acid is a medication primarily used to treat seizure disorders, bipolar disorder, and to prevent migraine headaches. It works by increasing the amount of a certain natural substance (GABA) in the brain. 

1. What Is Valproic Acid? 

Valproic acid is an anticonvulsant and mood-stabilizing drug. It is used to treat epilepsy, certain types of seizures, bipolar disorder, and to prevent migraine headaches. The drug helps to calm the overactive electrical activity in the brain. 

2. Why Is the Valproic Acid Test Performed? 

The test is used to monitor the level of valproic acid in the blood to ensure it remains within a therapeutic range. This is crucial because levels that are too low may not prevent seizures, while levels that are too high can lead to toxicity. 

3. Therapeutic and Toxic Levels 

• Therapeutic Range: 50–100 µg/mL for seizure control. 
• Toxic Level: >150 µg/mL can lead to symptoms such as confusion, vomiting, dizziness, and liver damage. 

4. What Can Affect Valproic Acid Levels? 

• Dosage and timing of medication 
• Liver function and metabolic rate 
• Interactions with other medications (e.g., aspirin, phenytoin) 
• Age and overall health status 

5. How Is the Test Performed? 

• A blood sample is drawn from a vein, usually just before the next dose (trough level). 
• No special preparation is typically needed unless specified by a healthcare provider. 

6. When to See a Doctor 

• If experiencing signs of toxicity: confusion, fatigue, nausea, tremors, or jaundice 
• For routine monitoring if prescribed valproic acid long-term 
• If adjusting dosage or adding new medications 

🔹 Key Takeaways 

✅ Valproic acid levels must be monitored regularly to ensure safety and effectiveness. 
✅ High levels can lead to serious side effects, while low levels may be ineffective. 
✅ Always follow medical advice and attend scheduled lab monitoring appointments.