Comprehensive STD qPCR Panel

Comprehensive STD qPCR Panel

Advanced Molecular Diagnostics for Sexually Transmitted Infections

STI (Sexually Transmitted Infection), also referred to as STD (Sexually Transmitted Disease)

The Largest Comprehensive Sexually Transmitted Infections (STI) qPCR Panel offers a rapid, highly sensitive, and accurate molecular solution for detecting 39 prevalent STI pathogens (including 16 HPV Genotypes with risk classification) and 44 major antibiotic resistance (ABR) genes.

Key Statistics (CDC, 2018):

- 1 in 5 individuals in the U.S. were living with an STI on any given day

- 26 million new STI cases were reported

- Nearly 50% of new cases involved people aged 15–24

- STI-related healthcare costs reached approximately $16 billion

Clinical Advantages

• High Sensitivity & Specificity for accurate detection of major STI pathogens

• Detects Antibiotic Resistance markers such as methicillin, vancomycin, and MDR genes

• Rapid Turnaround Time: Results typically within 5–24 hours

• Actionable Reports: Clear summaries with antimicrobial guidance

• Molecular Superiority: PCR testing exceeds traditional methods like cultures

• Enables Early Diagnosis: Facilitates timely treatment and reduces spread

Public Health Impact

The U.S. Department of Health and Human Services (DHHS) highlights the importance of early STI detection. While not all STIs are curable, timely diagnosis helps control symptoms, minimize complications, and prevent transmission.

Specimen Types

• Urogenital swabs (vaginal, endocervical, urethral)

• Urine (first-catch)

• Rectal swabs

• Pharyngeal swabs

• Lesion swabs (for HSV or syphilis)

Pathogen Detection Panel

Viruses

• Human Herpesvirus 5 (HHV-5 – Cytomegalovirus)

• Herpes Simplex Virus 1 (HSV-1)

• Herpes Simplex Virus 2 (HSV-2)

• HPV 16 – High-risk (most oncogenic)

• HPV 18 – High-risk

• HPV 45 – High-risk

• HPV 33 – High-risk

• HPV 58 – High-risk

• HPV 31 – High-risk

• HPV 52 – High-risk

• HPV 39 – High-risk

• HPV 56 – High-risk

• HPV 68 – Possibly high-risk

• HPV 06 – Low-risk

• HPV 11 – Low-risk

• HPV 35 – High-risk

• HPV 51 – High-risk

• HPV 66 – Possibly high-risk

• HPV 59 – High-risk

Bacteria

• Chlamydia trachomatis

• Gardnerella vaginalis

• Neisseria gonorrhoeae

• Staphylococcus aureus

• Treponema pallidum

• Streptococcus pyogenes (Group A)

• Streptococcus agalactiae (Group B)

• Mycoplasma genitalium

• Mycoplasma hominis

• Ureaplasma parvum

• Ureaplasma urealyticum

Fungi (Candida species)

• Candida auris

• Candida albicans

• Candida glabrata

• Candida parapsilosis

• Candida tropicalis

• Candida lusitaniae

• Candida kruseii (Pichia kudriavzevii)

Protozoa

• Trichomonas vaginalis

44 Antibiotic Resistance Genes (ABRs)

blaACC:   Acinetobacter-derived cephalosporinase

blaACT:   AmpC-type cephalosporinase

blaCMY:   Citrobacter freundii-derived AmpC-type beta-lactamase

blaLAT:   Latent AmpC-type beta-lactamase

blaFOX:   Cephamycin-hydrolyzing AmpC beta-lactamase

blaGES:   Guiana extended-spectrum beta-lactamase

blaMIR:   Morganella morganii-inducible cephalosporinase

blaVIM:   Verona integron-encoded metallo-beta-lactamase

Cfr:   Chloramphenicol-florfenicol resistance methyltransferase

CMY/MOX/DHA:   AmpC-type beta-lactamases (CMY, MOX, DHA families)

CTX-M_1:   Cefotaximase-Munich beta-lactamase group 1

CTX-M_2:   Cefotaximase-Munich beta-lactamase group 2

CTX-M_8_25:   Cefotaximase-Munich beta-lactamase groups 8 and 25

CTX-M_9:   Cefotaximase-Munich beta-lactamase group 9

dfrA1:   Trimethoprim-resistant dihydrofolate reductase type A1

dfrA5:   Trimethoprim-resistant dihydrofolate reductase type A5

ermA:   Erythromycin ribosome methylation A gene

ErmB:   Erythromycin ribosome methylation B gene

ErmC:   Erythromycin ribosome methylation C gene

IMP-1:   Imipenemase metallo-beta-lactamase type 1

IMP-2:   Imipenemase metallo-beta-lactamase type 2

KPC:   Klebsiella pneumoniae carbapenemase

MCR-1:   Mobile colistin resistance gene 1

MecA:   Methicillin resistance gene A

MecC:   Methicillin resistance gene C

mefA:   Macrolide efflux gene A

NDM:   New Delhi metallo-beta-lactamase

OXA-48:   Oxacillinase-48 carbapenemase

OXA-51:   Oxacillinase-51 carbapenemase (Acinetobacter)

PER-1:   Pseudomonas extended resistance beta-lactamase

qnrA:   Quinolone resistance protein A

QnrB_1of4:   Quinolone resistance protein B (variant 1 of 4)

QnrB_2of4:   Quinolone resistance protein B (variant 2 of 4)

QnrB_3of4:   Quinolone resistance protein B (variant 3 of 4)

QnrB_4of4:   Quinolone resistance protein B (variant 4 of 4)

qnrS:   Quinolone resistance protein S

SHV:   Sulfhydryl variable beta-lactamase

Sul1:   Sulfonamide resistance gene 1

Sul2:   Sulfonamide resistance gene 2

Tet(M):   Tetracycline resistance protein M

Tet(S):   Tetracycline resistance protein S

vanA2:   Vancomycin resistance gene cluster A2

vanB:   Vancomycin resistance gene cluster B

VEB:   Vietnamese extended-spectrum beta-lactamase