Lipase

The Lipase test measures the level of the enzyme lipase in the blood. Lipase is produced mainly by the pancreas and plays a critical role in the digestion of dietary fats. Elevated lipase levels are commonly used to diagnose and monitor pancreatitis and other pancreatic disorders.

1. What Is Lipase?

• Lipase is an enzyme that helps break down fats into smaller molecules during digestion.

• It is secreted by the pancreas into the small intestine, where it aids in fat absorption.

• When the pancreas is inflamed or damaged, lipase can leak into the bloodstream, increasing blood levels.

2. Why Is the Lipase Test Performed?

This test is used to:

• Diagnose acute or chronic pancreatitis.

• Evaluate abdominal pain or digestive symptoms.

• Monitor pancreatic disorders or assess response to treatment.

• Help identify conditions affecting the pancreas, gallbladder, or intestines.

3. Lipase Reference Range

• Normal range: 10 – 140 U/L (units per liter)

• Ranges may vary slightly between laboratories.

4. Interpreting Lipase Results

🔹 Elevated Lipase:

• Suggests pancreatitis (typically 3–10 times above normal levels).

• May also be elevated in gallstones, peptic ulcers, bowel obstruction, or kidney disease.

🔹 Low or Normal Lipase:

• Generally indicates no current pancreatic inflammation.

• Low levels are rarely clinically significant.

5. What Can Affect Lipase Levels?

• Acute or chronic pancreatitis

• Pancreatic tumors or trauma

• Kidney or liver disease (affects clearance)

• Medications (e.g., opioids, diuretics)

6. How Is the Test Performed?

• A blood sample is taken from a vein.

• Fasting may be required, depending on your doctor’s recommendations.

7. When to See a Doctor

🚨 Contact your healthcare provider if you:

• Experience sudden or severe abdominal pain, nausea, vomiting, or fever.

• Have a history of pancreatic disease or risk factors for pancreatitis (e.g., alcohol use, gallstones).

• Receive abnormal lipase results and need further diagnostic testing.

🔹 Key Takeaways

✅ Lipase is an important marker for diagnosing and monitoring pancreatic conditions.

✅ Elevated lipase is strongly associated with pancreatitis.

✅ Interpretation should consider clinical symptoms and other diagnostic tests.