Herpes Simplex Virus 2 (HSV-2) IgG

The Herpes Simplex Virus 2 (HSV-2) IgG test detects IgG antibodies in the blood, indicating a past infection with HSV-2. HSV-2 is typically associated with genital herpes, though it can sometimes cause oral lesions. This test helps determine whether someone has been previously exposed to HSV-2, even if they have never had symptoms.

1. What Is HSV-2 IgG?

• HSV-2 is a virus that primarily causes genital herpes, spread through sexual contact.

• The immune system produces IgG antibodies 2–6 weeks after exposure to the virus.

• A positive result indicates prior exposure and lifelong presence of the virus in the body.

2. Why Is the Test Performed?

This test is used to:

• Determine whether a person has been infected with HSV-2 in the past.

• Diagnose herpes when symptoms are absent, unclear, or not active.

• Screen individuals with partners who have genital herpes.

• Identify asymptomatic carriers who may unknowingly transmit the virus.

3. Interpreting HSV-2 IgG Test Results

🔹 Positive (Reactive):

• Indicates past infection with HSV-2.

• The virus remains in the body and may reactivate, especially during times of stress or weakened immunity.

• Does not indicate an active outbreak or contagiousness at the moment of testing.

🔹 Negative (Non-reactive):

• No detectable HSV-2 IgG antibodies — likely no past infection.

• If recent exposure is suspected, repeat testing may be necessary after a few weeks.

4. What Can Affect Test Accuracy?

• Testing too soon after exposure may yield false negatives.

• Immunosuppression may delay or impair antibody development.

• Cross-reactivity between HSV-1 and HSV-2 is possible, especially in non-type-specific tests.

5. How Is the Test Performed?

• A blood sample is collected from a vein.

• No fasting or special preparation is required.

6. When to See a Doctor

🚨 Contact your healthcare provider if you:

• Have or are concerned about genital symptoms (sores, itching, tingling).

• Are planning to start a new relationship and want to know your herpes status.

• Are pregnant and may need evaluation to protect your baby during delivery.

🔹 Key Takeaways

✅ HSV-2 IgG testing reveals past exposure to genital herpes, even without symptoms.

✅ A positive result means lifelong viral presence, with the possibility of recurrence.

✅ The test helps with diagnosis, screening, and informed health decisions.